Endocrine Abstracts

Bariatric surgery is known to improve obesity-induced systemic inflammation and glucose homeostasis, however, the exact mechanisms behind this effect are not fully understood. We have previously shown that Sodium Glucose Transporter 2 (SGLT2) is significantly inhibited in the kidney cortex following Vertical Sleeve Gastrectomy (VSG), causing a reduction in renal glucose reabsorption. In this study, we hypothesize that the observed post-operative reduction of SGLT2 is controlle...

Currently, most Type 2 Diabetes (T2D) treatments are targeted for the mitigation of the disease rather than remission. It has been previously demonstrated that T2D remission post-bariatric surgery in mice is independent of weight loss, indicating a metabolic mechanism. One avenue that remains largely unexplored is the role of cortisol, a hormone secreted from the adrenal cortex, dysregulation of which is linked to insulin resistance and obesity. The enzyme 11β-Hydroxyster...